About 27 percent of Americans die of heart disease, and the first sign may be sudden death. A revolutionary study in the fall issue of the Journal of American Physicians and Surgeons shows that about 90 percent of patients who experienced a cardiac event had a specific pattern present in a urine specimen contributed to a sample bank as long as 30 months before the diagnosis of heart disease. Other identifiable patterns were also present in patients later found to have breast cancer or prostate cancer.
The analytical technique uses magnetic resonance mass spectrometry, which determines the ratios of more than 800 substances present in a tiny drop of urine.
The concept of metabolic profiling, focused on easily and cheaply measured substances found in body fluids, was pioneered by Arthur Robinson and his colleagues at the University of California at San Diego, Stanford University, and the Linus Pauling Institute of Science and Medicine in the 1970s. Patterns were found to exist for many conditions, including multiple sclerosis, muscular dystrophy, and Huntington disease. Progress was limited by technology and the lack of longitudinal samples.
The Oregon Institute of Science and Medicine has developed a urine sample bank with cryogenically preserved specimens from 5,000 volunteers, who periodically send samples and medical information. If enough subjects develop a condition of interest, these samples can be analyzed. Once a library of profiles is compiled, information from individual patients’ serial samples could be used to monitor their health quantitatively and assess the effect of interventions on the probability of developing a full-blown disease.
Unlike other methods that focus on expensive measurements of a few substances characteristic of a specific disease, this research aims to develop a frequently repeatable $5 test that measures all common metabolic products whose relative concentrations are influenced by disease processes. As this bank is expanded and matures, it will make possible the discovery of profiles for less prevalent diseases. One single test that everyone could afford has the potential to determine the probability of most diseases.
Currently, this is a research technique only. Federal law prohibits use of the information to diagnose or treat patients.
The Institute is entirely supported by donations and grants from private individuals and foundations and by the independent earnings and resources of its faculty and volunteers. It does not solicit or accept tax-financed government funds. The Institute has a modest endowment, no debts, and a policy of incurring none. It is classified by the IRS as a 501(c)3 public foundation.
The Institute currently has six faculty members, several regular volunteers, and a larger number of other volunteers who work on occasional projects. Most of the Institute's work is carried out in a modern 7,000 square foot research laboratory, which includes a full complement of equipment for work in biochemistry and molecular biology and some specialized equipment including a Bruker ion cyclotron resonance Fourier transform mass spectrometer for work on protein deamidation.
Current projects include work on the deamidation of peptides and proteins as it relates to fundamental biochemistry and to protein aggregation diseases such as Parkinson's disease and Alzheimer's disease; research on improved techniques for medical diagnosis; improvement in precollege education curricula, especially in the sciences; and improved civilian emergency preparedness.
Several members of the Institute's staff are also well known for their work on the Petition Project, an undertaking that has obtained the signatures of more than 31,000 American scientists opposed, on scientific grounds, to the hypothesis of "human-caused global warming" and to concomitant proposals for world-wide energy taxation and rationing. The Petition Project does not utilize any Oregon Institute of Science and Medicine resources or funds. It also has no funding from energy industries or other parties with special interests in the "global warming" debate. Funding for the project comes entirely from private donations by interested individuals, primarily readers of the newsletter Access to Energy that is independently published.